Royal Air Force Typhoon FGR4s have joined forces with French warplanes in a combined operation on an hidden munitions depot in Syrian territory used by the IS group, per a report from the British defence ministry.
The site, located using surveillance, was thought to be containing munitions and bombs, the announcement noted, and was located in hills just north of Palmyra in Syria's central region.
"Our aircraft employed Paveway IV guided bombs to hit a several approach shafts providing entry to the facility... preliminary assessments suggest the strike was effective," the MoD said.
There was no evidence of any harm to civilians in the attack conducted Saturday night and each participating jet returned to base without incident, the MoD added.
The British jets were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as the so-called Islamic State - enforced militant control over significant areas in Syria and Iraq prior to its 2019 collapse.
"This operation shows the UK's leading role, and resolve to operate in unison with our partners, to eradicate any revival of Daesh and their violent and radical beliefs in the Middle East," the British Defence Secretary John Healey remarked.
RAF aircraft have carried out overwatch operations over Syrian airspace to "deter any attempted comeback" of IS following its defeat at the Baghuz confrontation in 2019, the ministry said.
"I must thank every member of British forces involved in this strike for their expertise and their bravery," the Defence Secretary added. "Including them were thousands of British personnel deployed over Christmas and New Year. This action, to take out dangerous terrorists who pose a risk to our safety, demonstrates how UK forces are ready to step up, all year round, keeping Britain secure domestically and powerful internationally."
Last December, the American forces executed what it described as a "major assault" against Islamic State objectives in the country, after an assault resulted in the deaths of two American soldiers and a local interpreter in the Palmyra area.
The UN says Islamic State still maintains between 5,000 and 7,000 militants in both countries.